Archie Enninful ‘26

(he/him)

Home Department: Biomedical Engineering (Fan Lab)

Research Project: Spatial multi-omic analysis of human lymphoid tissues

Cancers of the lymph nodes such as Diffuse Large B Cell Lymphoma (DLBCL) have been notoriously difficult to treat given their heterogeneous clinical behavior and high relapse rate. Despite recent advancements in our understanding of these malignancies through clinical molecular testing, knowledge gaps persist, hindering the development of tailored therapeutic interventions. In light of the intricate molecular and cellular intricacies of DLBCL, we utilize multiplexed immunofluorescence and sequencing-based spatial transcriptomics and proteomics to characterize cell type composition, their interactions, and changes associated with disease progression in these lymphomas. This research endeavor represents a critical step towards unraveling the enigma surrounding these malignancies, ultimately revolutionizing the landscape of hematologic oncology research and patient care.

Relevant Publications

Liu et al. (2023) “High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq”