Imaging Biological Systems

What can we learn from imaging cells, tissues, and organisms? Labs working in imaging and optics are pushing the limits of light, fluorescence, and electron microscopy approaches to create images and movies that with higher spatial and temporal resolution. Once the images are acquired, researchers working in the area of image analysis are discovering new ways to analyze and quantify these images.

Featured Research

Dynamic speckle illumination microscopy with tailored speckle statistics

SeungYun Han ‘26

he/him

Applied Physics (Cao Lab)

Left: SeungYun working in the lab; Right: example of SeungYun's data

Wavefront Shaping of Light in Scattering Media

Rohin McIntosh ‘27

he/him

Physics (Cao Lab)

Rohin in the lab (left) and diagrams depicting the impact of shaped wavefronts on imaging (right)

Understanding ultrafast peptide dynamics in cells using Fast Relaxation Imaging

Raibat Sarker ‘28

he/him

Chemistry (Davis Lab)

Left: Raibat in the lab; Right: Raibat's imaging setup can be used to image protein in vitro and in vivo

Faculty

  • Sean Barrett

    Professor; Physics and Applied Physics
    • Imaging Biological Systems
    Research Interests: Experimental condensed matter physics; NMR method development
  • Julien Berro

    Associate Professor: Molecular Biophysics & Biochemistry and Cell Biology
    • Imaging Biological Systems
    • Properties, Structure, Composition of Biological Systems
    Research Interests: Actin and cytoskeleton; clatherin mediated endocytosis; mathematical modeling combined with experiment; imaging
  • Joerg Bewersdorf

    Professor: Cell Biology, Biomedical Engineering, and Physics
    • Imaging Biological Systems
    Research Interests: Super resolution imaging; nanoscopy
  • Hui Cao

    Professor; Applied Physics, Physics, and Electrical Engineering
    • Imaging Biological Systems
    Research Interests: Biophotonics; Nanophotonics; Complex optical materials and phenomena
  • Alicia Che

    Assistant Professor; Psychiatry
    • Biological Circuits
    • Imaging Biological Systems
    Research Interests: Structure and function of cortical networks: neuronal circuits; optical imaging
  • Caitlin Davis

    Assistant Professor; Chemistry
    • Imaging Biological Systems
    • Properties, Structure, Composition of Biological Systems
    Research Interests: Using time-resolved spectral imaging at multiple scales, from in vitro to single cell to whole organism, to make connections between molecular mechanisms and cellular function
  • Paul Forscher

    Professor; Molecular, Cellular & Developmental Biology
    • Imaging Biological Systems
    • Properties, Structure, Composition of Biological Systems
    Research Interests: Actin assembly; cytoskeletal protein dynamics; cellular motion; microscopy
  • Scott Holley

    Professor; Molecular, Cellular & Developmental Biology
    • Bioinformatics
    • Biological Circuits
    • Computational Biology
    • +3 more
    Research Interests: The systems biology, biomechanics and molecular biophysics of early spinal column development
  • Joe Howard

    Professor; Molecular Biophysics & Biochemistry and Physics
    • Computational Biology
    • Imaging Biological Systems
    • Neuroscience
    • +2 more
    Research Interests: Microtubules and molecular motors. Branching morphogenesis of neurons. Motility of cilia and flagella. Nerve nets.
  • Aaron Kuan

    Assistant Professor; Neuroscience and Biomedical Engineering
    • Bioinformatics
    • Biological Circuits
    • Computational Biology
    • +2 more
    Research Interests: Electron microscopy and X-ray imaging techniques to enable 3D imaging of neuronal circuits combined with behavior and functional imaging to reveal how circuit connectivity underlies brain activity and cognition.
  • Roy Lederman

    Assistant Professor; Statistics and Data Science
    • Bioinformatics
    • Computational Biology
    • Imaging Biological Systems
    Research Interests: Cryo-EM; numerical analysis and signal processing; geometry of data; computational biology algorithms; mathematics of data science
  • Liang Liang

    Assistant Professor; Neuroscience
    • Biological Circuits
    • Imaging Biological Systems
    • Neuroscience
    Research Interests: Synaptic and neural circuit mechanisms underlying visual information processing; combining recording of neural activity in awake behaving animals, image processing, and computational modeling
  • Yimin Luo

    Assistant Professor; Mechanical Engineering & Materials Science
    • Imaging Biological Systems
    • Properties, Structure, Composition of Biological Systems
    Research Interests: Regulated cell alignment and tissue organization are vital in health and disease. To systematically investigate how cells respond to patterns, we achieve precise control over their arrangement through molecularly defined scaffolds. We innovate a continuous imaging platform tracking thousands of cells over days. Leveraging reams of data, we develop a hybrid procedure that utilizes statistical learning approaches to extend the state-of-the-art physics models.
  • Zongming Ma

    Professor; Statistics and Data Science
    • Bioinformatics
    • Imaging Biological Systems
    Research Interests: Developing machine learning and statistical tools to gain biological insights from spatial and single-cell data
  • Nikhil Malvankar

    Associate Professor; Molecular Biophysics & Biochemistry
    • Bioengineering
    • Bioinformatics
    • Biological Circuits
    • +3 more
    Research Interests: We are developing electronic Imaging & Control of Microbial Functions, by studying how environmentally and clinically important microbes build & use hair-like “nanowires” to export electrons outside their cell body, during respiration, communication, and pathogenesis and by tuning nanowire conductivity using light, pressure, temperature, electromagnetic fields, and non-natural ‘click’ chemistry.
  • Kirstin Meyer

    Assistant Professor; Molecular, Cellular, and Developmental Biology
    • Bioengineering
    • Biological Circuits
    • Imaging Biological Systems
    • +1 more
    Research Interests: We seek to understand molecular mechanisms of emergent gene regulatory behavior, with a focus on temporal information transmission, mechanosensing, and chromatin biophysics.
  • Simon Mochrie

    Professor; Physics and Applied Physics
    • Bioinformatics
    • Biological Circuits
    • Computational Biology
    • +2 more
    Research Interests: Quantitative microscopy and image analysis. Chromatin organization and dynamics. Nuclear envelope physics. Phase transitions of soft matter
  • Binyam Mogessie

    Assistant Professor; Molecular, Cellular & Developmental Biology and Obstetrics, Gynecology & Reproductive Sciences
    • Imaging Biological Systems
    • Properties, Structure, Composition of Biological Systems
    Research Interests: The Mogessie lab studies cytoskeletal organization and function with a special focus on chromosome segregation in mammalian eggs and the molecular origins of female reproductive aging and infertility.
  • Michael Murrell

    Associate Professor; Biomedical Engineering and Physics
    • Bioengineering
    • Biological Circuits
    • Imaging Biological Systems
    • +1 more
    Research Interests: Non-equilibrium thermodynamics, active matter, biophysics, synthetic biology, cytoskeletal mechanics.
  • Hesper Rego

    Associate Professor; Microbial Pathogenesis
    • Biological Circuits
    • Imaging Biological Systems
    • Properties, Structure, Composition of Biological Systems
    Research Interests: Imaging (including building microscopes), single-cell level experiments, mycobacterial infections, drivers of heterogeneity
  • Xiaolei Su

    Assistant Professor; Cell Biology
    • Bioengineering
    • Biological Circuits
    • Imaging Biological Systems
    • +1 more
    Research Interests: Membranes, phase separation, and regulation of immune signaling; single molecule imaging and cell engineering
  • Jing Yan

    Assistant Professor, Molecular, Cellular & Developmental Biology
    • Bioengineering
    • Biological Circuits
    • Computational Biology
    • +3 more
    Research Interests: Imaging and modeling the developmental process of bacterial communities, characterizing and understanding the soft matter properties of bacterial biofilms, designing new bioinspired materials and surfaces