Systems Biology

How do individual components come together to create complex biological phenomena? Researchers studying collective behavior work to understand how a group of individual organisms or cells coordinate their behavior to achieve a desired outcome. Labs working on cancer systems biology and systems immunology work to understand the intricate interplay between different cell types and signaling pathways during the progression of cancer and the immune response, respectively. 

Featured Research

Investigating non-genetic adaptation by collective migration

Lam Vo ‘26

he/him

Molecular, Cellular, and Developmental Biology (Emonet Lab)

Left: Lam in the lab, Right: Graphical abstract of Lam's research

Characterizing transcription factor networks that tune macrophage heterogeneity

Iyad Sayed Issa ‘27

he/him

Molecular, Cellular, and Developmental Biology (Miller-Jensen Lab)

Left: Iyad in the lab; Right: Schematic of how immune cells might react to signals

Faculty

  • Marcus Bosenberg

    Professor; Dermatology, Pathology, and Immunobiology
    • Bioinformatics
    • Biological Circuits
    • Systems Biology
    Research Interests: Melanoma biology; soft tissue tumors
  • John Carlson

    Professor; Molecular, Cellular & Developmental Biology
    • Biological Circuits
    • Systems Biology
    Research Interests: Molecular basis of olfaction, taste, and pheromone perception
  • Hattie Chung

    Assistant Professor; Cardiovascular Medicine and Molecular, Cellular, and Developmental Biology
    • Biological Circuits
    • Computational Biology
    • Systems Biology
    Research Interests: We study the molecular basis of cellular heterogeneity and tissue organization in health and disease through the lens of systems biology by pioneering novel computational and experimental tools, with applications to cardiovascular disease and ovarian aging.
  • Martina Dal Bello

    Assistant Professor; Ecology and Evolutionary Biology
    • Bioinformatics
    • Computational Biology
    • Systems Biology
    Research Interests: research in the Dal Bello lab focuses on how microbes respond to and modify their environment, and how these feedback processes shape species interactions, assembly processes, and the function of microbial communities.
  • Purushottam Dixit

    Assistant Professor; Biomedical Engineering
    • Bioinformatics
    • Biological Circuits
    • Computational Biology
    • +1 more
    Research Interests: Build machine learning methds that are rooted in statistical physics to analyze high quality high dimensional “omics” data from biological systems
  • Thierry Emonet

    Professor; Molecular, Cellular & Developmental Biology and Physics
    • Biological Circuits
    • Computational Biology
    • Neuroscience
    • +1 more
    Research Interests: We combine theory and experiments to understand the computations organisms perform to navigate chemical environments. Bacteria: we analyze information processing in individual cells, the molecular basis of individuality, and how biological diversity benefits populations. Fruit flies: we examine how insects perform goal oriented olfactory navigation, and how they adapt decision-making strategies in real time as odor signal statistics and environmental conditions change
  • Rong Fan

    Professor; Biomedical Engineering
    • Bioinformatics
    • Biological Circuits
    • Properties, Structure, Composition of Biological Systems
    • +1 more
    Research Interests: Combining single-cell analysis technology and systems biology to study cell-cell communication and cellular heterogeneity in human cancers and the immune system
  • Scott Holley

    Professor; Molecular, Cellular & Developmental Biology
    • Bioinformatics
    • Biological Circuits
    • Computational Biology
    • +3 more
    Research Interests: The systems biology, biomechanics and molecular biophysics of early spinal column development
  • Joe Howard

    Professor; Molecular Biophysics & Biochemistry and Physics
    • Computational Biology
    • Imaging Biological Systems
    • Neuroscience
    • +2 more
    Research Interests: Microtubules and molecular motors. Branching morphogenesis of neurons. Motility of cilia and flagella. Nerve nets.
  • Farren Isaacs

    Professor; Molecular, Cellular & Developmental Biology
    • Bioengineering
    • Bioinformatics
    • Biological Circuits
    • +2 more
    Research Interests: Synthetic Biology, Genome Engineering, Systems Biology, Bioengineering, Engineered biomaterials & RNAs
  • Christopher Lynn

    Assistant Professor; Physics
    • Biological Circuits
    • Computational Biology
    • Neuroscience
    • +1 more
    Research Interests: Understanding how structure and function emerge in complex living systems, particularly the brain.
  • Michael Mak

    Assistant Professor; Biomedical Engineering
    • Computational Biology
    • Properties, Structure, Composition of Biological Systems
    • Systems Biology
    Research Interests: Multiscale mechanobiology in cancer and development, from molecular to multicellular levels, integrating microfluidics, wet-lab experiments, and computational approaches.
  • Nikhil Malvankar

    Associate Professor; Molecular Biophysics & Biochemistry
    • Bioengineering
    • Bioinformatics
    • Biological Circuits
    • +3 more
    Research Interests: We are developing electronic Imaging & Control of Microbial Functions, by studying how environmentally and clinically important microbes build & use hair-like “nanowires” to export electrons outside their cell body, during respiration, communication, and pathogenesis and by tuning nanowire conductivity using light, pressure, temperature, electromagnetic fields, and non-natural ‘click’ chemistry.
  • Harry McNamara

    Assistant Professor; Molecular, Cellular & Developmental Biology
    • Bioengineering
    • Biological Circuits
    • Neuroscience
    • +1 more
    Research Interests: Synthetic developmental biology: measuring and controlling stem cells to understand how they self-organize multicellular structures in vitro (organoids, embryoids)
  • Kirstin Meyer

    Assistant Professor; Molecular, Cellular, and Developmental Biology
    • Bioengineering
    • Biological Circuits
    • Imaging Biological Systems
    • +1 more
    Research Interests: We seek to understand molecular mechanisms of emergent gene regulatory behavior, with a focus on temporal information transmission, mechanosensing, and chromatin biophysics.
  • Kathryn Miller-Jensen

    Associate Professor; Biomedical Engineering and Molecular, Cellular & Developmental Biology
    • Bioengineering
    • Systems Biology
    Research Interests: HIV latency; signaling pathways; high-throughput single cell analysis; computational, experimental and systems-level approaches
  • Michael Murrell

    Associate Professor; Biomedical Engineering and Physics
    • Bioengineering
    • Biological Circuits
    • Imaging Biological Systems
    • +1 more
    Research Interests: Non-equilibrium thermodynamics, active matter, biophysics, synthetic biology, cytoskeletal mechanics.
  • Corey O'Hern

    Professor; Mechanical Engineering & Materials Science, Physics, Applied Physics and Graduate Program in Computational Biology & Bioinformatics
    • Computational Biology
    • Properties, Structure, Composition of Biological Systems
    • Systems Biology
    • +1 more
    Research Interests: Statistical mechanics of nonequilibrium systems; glass and jamming transitions in soft matter; computational biology; protein structure, interactions, and design.
  • Edward Stites

    Associate Professor; Laboratory Medicine & Pathology
    • Bioengineering
    • Bioinformatics
    • Biological Circuits
    • +2 more
    Research Interests: mathematical modeling, informed machine learning, cancer biology/disease biology, systems biology, synthetic biology
  • John Tsang

    Professor; Immunobiology and Biomedical Engineering
    • Bioengineering
    • Bioinformatics
    • Biological Circuits
    • +2 more
    Research Interests: Systems and quantitative immunology; human immunology; single cell biology; predicting and modeling immune responses; synthetic immunology: predictive engineering of immune cell trafficking and sensing; immune homeostasis maintenance and set point establishment mechanisms; integrating dynamical modeling and machine learning to understand emergent immune system behavior across temporal and spatial scales.
  • Min Wu

    Associate Professor; Cell Biology
    • Biological Circuits
    • Computational Biology
    • Properties, Structure, Composition of Biological Systems
    • +1 more
    Research Interests: Single cell oscillations and travelling waves, membrane curvature, mitosis, cell size
  • Jing Yan

    Assistant Professor, Molecular, Cellular & Developmental Biology
    • Bioengineering
    • Biological Circuits
    • Computational Biology
    • +3 more
    Research Interests: Imaging and modeling the developmental process of bacterial communities, characterizing and understanding the soft matter properties of bacterial biofilms, designing new bioinspired materials and surfaces